产品货号：
Z12101
中文名称：
BRCA1抗体
英文名称：
Anti-BRCA1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-BRCA1 Antibody |
| 指标别名 | BRCA1;BRCAI;BRCC1;breast cancer 1;early onset;BROVCA1;IRIS;PSCP;RING finger protein 53;RNF53 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,FCM |
| 基因名称 | BRCA1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human BRCA1 recombinant protein (Position:E1661-Y1863).Human BRCA1 shares 65% and 66% amino acid (aa) sequence identity with mouse and rat BRCA1,respectively. |
| 实际分子量 | 290KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | BRCA1,also known as BRCC1,is a gene which mapping to 17q21.3.This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability,and it also acts as a tumor suppressor.The encoded protein combines with other tumor suppressors,DNA damage sensors,and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC).BRCA1 product associates with RNA polymerase II,and through the C-terminal domain,also interacts with histone deacetylase complexes.This protein thus plays a role in transcription,DNA repair of double-stranded breaks,and recombination.In addition to it,BRCA1 may normally serve as a negative regulator of mammary epithelial cell growth and that this function is compromised in breast cancer either by direct mutation or by alterations in gene expression. |
| Uniprot ID | P38398 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | breast cancer 1,early onset |
| 蛋白名全称 | Breast cancer type 1 susceptibility protein |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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